Fmoc-Cit-OH
Fmoc-Cit-OH (Fmoc-L-Citrulline) is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize a degradable ADC linker composed of a valine-citrulline (Val-Cit) motif[1].
Product Specifications
CAS Number
[133174-15-9]
Product Name Alternative
Fmoc-L-Citrulline
UNSPSC
12352209
Hazard Statement
H302, H315, H319, H335
Target
Amino Acid Derivatives
Type
Peptides
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fmoc-cit-oh.html
Purity
99.76
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC(NCCC[C@@H](C(O)=O)NC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)=O
Molecular Formula
C21H23N3O5
Molecular Weight
397.42
Precautions
H302, H315, H319, H335
References & Citations
[1]Pryyma, et al. "Rapid, high-yielding solid-phase synthesis of cathepsin-B cleavable linkers for targeted cancer therapeutics." Bioconjugate Chemistry 31.12 (2020) : 2685-2690.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
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