Fmoc-Cit-OH

Fmoc-Cit-OH (Fmoc-L-Citrulline) is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize a degradable ADC linker composed of a valine-citrulline (Val-Cit) motif[1].

Product Specifications

CAS Number

[133174-15-9]

Product Name Alternative

Fmoc-L-Citrulline

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

Amino Acid Derivatives

Type

Peptides

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/fmoc-cit-oh.html

Purity

99.76

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NC(NCCC[C@@H](C(O)=O)NC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)=O

Molecular Formula

C21H23N3O5

Molecular Weight

397.42

Precautions

H302, H315, H319, H335

References & Citations

[1]Pryyma, et al. "Rapid, high-yielding solid-phase synthesis of cathepsin-B cleavable linkers for targeted cancer therapeutics." Bioconjugate Chemistry 31.12 (2020) : 2685-2690.