Stearoylcarnitine

Stearoylcarnitine, a fatty ester lipid molecule, is an endogenous metabolite. Stearoylcarnitine can be used as PKC inhibitor. Stearoylcarnitine accumulates in β cells, leading to arrest of insulin synthesis and energy deficiency in type 2 diabetes mouse. Stearoylcarnitine inhibits lecithin cholesterol acyltransferase (LCAT) in rat and rabbits plasma. Stearoylcarnitine acts as a metabolomics biomarker for Parkinson’s disease. Stearoylcarnitine is a less potent inhibitor of GlyT2[1][2][3][4][5].

Product Specifications

CAS Number

[25597-09-5]

Product Name Alternative

5-(4-Phenoxybutoxy)psoralen,ZM-211973

UNSPSC

12352211

Target

Endogenous Metabolite; GlyT; PKC

Type

Natural Products

Related Pathways

Epigenetics; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; TGF-beta/Smad

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Stearoylcarnitine.html

Purity

99.91

Solubility

DMSO : 0.95 mg/mL (ultrasonic; warming; adjust pH to 6 with 0.1 N NaOH; heat to 60°C) |H2O : < 0.1 mg/mL (ultrasonic)

Smiles

CCCCCCCCCCCCCCCCCC(O[C@H](CC([O-])=O)C[N+](C)(C)C)=O

Molecular Formula

C25H49NO4

Molecular Weight

427.66

References & Citations

[1]Aichler M, et al. N-acyl Taurines and Acylcarnitines Cause an Imbalance in Insulin Synthesis and Secretion Provoking β Cell Dysfunction in Type 2 Diabetes. Cell Metab. 2017 Jun 6;25 (6) :1334-1347.e4.|[2]Dave AM, et al. Neonatal Hypoxic-Ischemic Brain Injury Alters Brain Acylcarnitine Levels in a Mouse Model. Metabolites. 2022 May 22;12 (5) :467.|[3]Bell FP. Carnitine esters: novel inhibitors of plasma lecithin: cholesterol acyltransferase in experimental animals but not in man (Homo sapiens) . Int J Biochem. 1983;15 (2) :133-6.|[4]Li XZ, et al. Cerebral metabonomics study on Parkinson's disease mice treated with extract of Acanthopanax senticosus harms. Phytomedicine. 2013 Oct 15;20 (13) :1219-29.|[5]da Luz G, et al. Triterpene derivative: A potential signaling pathway for the fern-9 (11) -ene-2α,3β-diol on insulin secretion in pancreatic islet. Life Sci. 2016 Jun 1;154:58-65.