AR-C118925XX
AR-C118925XX is a selective P2Y2 receptor antagonist. AR-C118925XX inhibits ATP-induced IL-6 production and phosphorylation of p38. AR-C118925XX also inhibits Bleomycin -induced dermal fibrosis in mice. AR-C118925XX also inhibits ATP-induced tumor growth[1][2].
Product Specifications
CAS Number
216657-60-2
UNSPSC
12352005
Hazard Statement
H228, H315, H319
Target
P2Y Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ar-c118925xx.html
Purity
99.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(CN2C=C(C3C4=CC=C(C)C=C4C=CC5=CC(C)=CC=C53)C(NC2=O)=S)O1)NC6=NN=NN6
Molecular Formula
C28H23N7O3S
Molecular Weight
537.59
Precautions
H228, H315, H319
References & Citations
[1]Perera LMB, et al. The Regulation of Skin Fibrosis in Systemic Sclerosis by Extracellular ATP via P2Y2 Purinergic Receptor. J Invest Dermatol. 2019 Apr;139 (4) :890-899. |[2]Dong CR, et al. AKT/GSK-3beta/VEGF signaling is involved in P2RY2 activation-induced the proliferation and metastasis of gastric cancer. Carcinogenesis. 2022 Dec 5:bgac095.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2Y2 Receptor
Available Sizes
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