SPT-IN-1

SPT-IN-1 (compound 1) is an orally active and potent SPT (serine palmitoyl transferase) inhibitor, with an IC50 of 5.19 nM for hSPT1. SPT-IN-1 can be used for type 2 diabetes and dyslipidemia research[1].

Product Specifications

CAS Number

[1933533-18-6]

UNSPSC

12352005

Hazard Statement

H302-H312-H332

Target

Ceramidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/spt-in-1.html

Purity

99.18

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

CCCCCCC(C1=CN2C=CN=C2C(C3=CC=C(CC(O)=O)C=C3)=C1)=O

Molecular Formula

C22H24N2O3

Molecular Weight

364.44

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]Genin MJ, et al. Imidazopyridine and Pyrazolopiperidine Derivatives as Novel Inhibitors of Serine Palmitoyl Transferase. J Med Chem. 2016;59 (12) :5904-5910.