A-887826
A-887826 is a potent, selective, oral bioavailable and voltage-dependent Na (v) 1.8 sodium channel blocker with an IC50 of 11 nM . A-887826 attenuates neuropathic tactile allodynia in vivo[1].
Product Specifications
CAS Number
[1266212-81-0]
UNSPSC
12352005
Hazard Statement
H301
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/a-887826.html
Concentration
10mM
Purity
99.10
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(C2=CC=C(OCCCC)C(Cl)=C2)=CN=C1)NCC3=CC=CN=C3N4CCOCC4
Molecular Formula
C26H29ClN4O3
Molecular Weight
480.99
Precautions
H301
References & Citations
[1]Zhang XF, et al. A-887826 is a structurally novel, potent and voltage-dependent Na (v) 1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats. Neuropharmacology. 2010 Sep;59 (3) :201-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Nav1.8
Available Sizes
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