Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

RBN013209

RBN013209 is an orally active small molecule inhibitor of CD38 with an IC50 of 0.01 to 0.1 μM for human CD38. RBN013209 prevents the conversion of extracellular NAD+ to ADPR or cADPR in tumor cells and PBMCs. RBN013209 can be used in the study of tumor. In addition, RBN013209 enables CAR-T cells to maintain the naive state and central memory state, and decreases the expression of cell activation markers and exhaustion-related inhibitory receptors[1][2][3].

Product Specifications

CAS Number

[2597933-17-8]

UNSPSC

12352005

Target

CD38; LAG-3; PD-1/PD-L1; Tim3

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/rbn013209.html

Concentration

10mM

Purity

98.63

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COCCO[C@@H](CC1)CC[C@H]1NC(C2=C3C(C=CN3)=NC(N4C=CN=C4)=N2)=O

Molecular Formula

C19H24N6O3

Molecular Weight

384.43

References & Citations

[1]Laurie B. Schenkel, et al. Heterobicyclic amides as inhibitors of cd38. WO2021021986A1.|[2]Shambharkar, et al. Small molecule inhibitor of CD38 modulates its intra-and extracellular functions leading to antitumor activity. Cancer Research 81.13_Supplement (2021) : 1344-1344.|[3]Huang Y, et al. Inhibition of CD38 enzymatic activity enhances CAR-T cell immune-therapeutic efficacy by repressing glycolytic metabolism. Cell Rep Med. 2024 Feb 20;5 (2) :101400.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-144987/RBN013209-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-144987/RBN013209-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

EEF1G sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)
18985111 3 x 1.0 µg

EEF1G sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)

Ask
View Details
Mouse Neurog2 Antibody (C-term)
E45R33101G-1 100 µL

Mouse Neurog2 Antibody (C-term)

Ask
View Details
Octahydroimidazolidino[1,5-a]piperazin-3-one hydrochloride
OR1039711-01 100 mg

Octahydroimidazolidino[1,5-a]piperazin-3-one hydrochloride

Ask
View Details
Octahydroimidazolidino[1,5-a]piperazin-3-one hydrochloride
OR1039711-02 250 mg

Octahydroimidazolidino[1,5-a]piperazin-3-one hydrochloride

Ask
View Details
Octahydroimidazolidino[1,5-a]piperazin-3-one hydrochloride
OR1039711-03 1 g

Octahydroimidazolidino[1,5-a]piperazin-3-one hydrochloride

Ask
View Details
Mouse DEFB12 shRNA Plasmid
abx978816-01 150 µg

Mouse DEFB12 shRNA Plasmid

Ask
View Details