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EGFR-IN-105

EGFR-IN-105 (Compound 5b) is an EGFR2 inhibitor with an IC50 value of 0.68 μM. EGFR-IN-105 exhibits anticancer activity and can induce apoptosis in cancer cells, which is used in the research of pancreatic cancer[1].

Product Specifications

CAS Number

831244-98-5

UNSPSC

12352005

Target

Apoptosis; EGFR

Type

Reference compound

Related Pathways

Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/egfr-in-105.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=C(C#N)C(CCC(C(C)(C)C)C2)=C2S1)CN3CCN(C)CC3

Molecular Formula

C20H30N4OS

Molecular Weight

374.54

References & Citations

[1]Rahman A, et al. Tetrahydrobenzothiophene derivatives ameliorate Mia PaCa-2 cell progression and induces apoptosis via inhibiting EGFR2 tyrosine kinase signal. Bioorg Chem. 2024 Feb;143:106968.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

ErbB2/HER2

Frequently Asked Questions

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