EGFR-IN-105
EGFR-IN-105 (Compound 5b) is an EGFR2 inhibitor with an IC50 value of 0.68 μM. EGFR-IN-105 exhibits anticancer activity and can induce apoptosis in cancer cells, which is used in the research of pancreatic cancer[1].
Product Specifications
CAS Number
831244-98-5
UNSPSC
12352005
Target
Apoptosis; EGFR
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-105.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=C(C#N)C(CCC(C(C)(C)C)C2)=C2S1)CN3CCN(C)CC3
Molecular Formula
C20H30N4OS
Molecular Weight
374.54
References & Citations
[1]Rahman A, et al. Tetrahydrobenzothiophene derivatives ameliorate Mia PaCa-2 cell progression and induces apoptosis via inhibiting EGFR2 tyrosine kinase signal. Bioorg Chem. 2024 Feb;143:106968.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ErbB2/HER2
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