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RH1

RH1 (NSC 697726) is a potent bioreductive agent with profound anti-cancer activity in vitro and in vivo.

Product Specifications

CAS Number

221635-42-3

Product Name Alternative

NSC 697726

UNSPSC

12352005

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/RH1.html

Purity

97.10

Solubility

DMSO : 1.25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C(N2CC2)=C(CO)C(C(N3CC3)=C1C)=O

Molecular Formula

C12H14N2O3

Molecular Weight

234.25

References & Citations

[1]Park MT, et al. The anti-tumour compound, RH1, causes mitochondria-mediated apoptosis by activating c-Jun N-terminal kinase. Br J Pharmacol. 2011 Jun;163 (3) :567-85.|[2]Dehn DL, et al. Development of a new isogenic cell-xenograft system for evaluation of NAD (P) H:quinone oxidoreductase-directed antitumor quinones: evaluation of the activity of RH1. Clin Cancer Res. 2004 May 1;10 (9) :3147-55.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

Phase 1

Available Sizes

Frequently Asked Questions

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