ULK1-IN-2
ULK1-IN-2 (compound 3s) is a potent ULK1 inhibitor. ULK1-IN-2 shows highest cytotoxic effect against cancer cell lines, with IC50 of 1.94 μM in A549. ULK1-IN-2 can induce apoptosis and simultaneously block autophagy, and can be used to study NSCLC (Non-small cell lung cancer) [1].
Product Specifications
CAS Number
2497409-01-3
UNSPSC
12352005
Target
AMPK; Apoptosis; Autophagy; FAK; ULK
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Epigenetics; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ulk1-in-2.html
Concentration
10mM
Purity
98.34
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
COC1=C(OC)C(OC)=CC(NC2=NC=C(Br)C(OC3=CC=C([N+]([O-])=O)C=C3F)=N2)=C1
Molecular Formula
C19H16BrFN4O6
Molecular Weight
495.26
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ULK1
Available Sizes
Frequently Asked Questions
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