ULK1-IN-2
Product Specifications
UNSPSC Description
ULK1-IN-2 (compound 3s) is a potent ULK1 inhibitor. ULK1-IN-2 shows highest cytotoxic effect against cancer cell lines, with IC50 of 1.94 μM in A549. ULK1-IN-2 can induce apoptosis and simultaneously block autophagy, and can be used to study NSCLC (Non-small cell lung cancer)[1].
Target Antigen
AMPK; Apoptosis; Autophagy; FAK; ULK
Type
Reference compound
Related Pathways
Apoptosis;Autophagy;Epigenetics;PI3K/Akt/mTOR;Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ulk1-in-2.html
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
COC1=C(OC)C(OC)=CC(NC2=NC=C(Br)C(OC3=CC=C([N+]([O-])=O)C=C3F)=N2)=C1
Molecular Weight
495.26
References & Citations
[1]Sun D, Yang Z, Zhen Y, et al. Discovery of 5-bromo-4-phenoxy-N-phenylpyrimidin-2-amine derivatives as novel ULK1 inhibitors that block autophagy and induce apoptosis in non-small cell lung cancer. Eur J Med Chem. 2020;208:112782.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-143466/ULK1-IN-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-143466/ULK1-IN-2-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2497409-01-3
Available Sizes
Curated Selection
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