ULK1-IN-2

ULK1-IN-2 (compound 3s) is a potent ULK1 inhibitor. ULK1-IN-2 shows highest cytotoxic effect against cancer cell lines, with IC50 of 1.94 μM in A549. ULK1-IN-2 can induce apoptosis and simultaneously block autophagy, and can be used to study NSCLC (Non-small cell lung cancer) [1].

Product Specifications

CAS Number

[2497409-01-3]

UNSPSC

12352005

Target

AMPK; Apoptosis; Autophagy; FAK; ULK

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Epigenetics; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ulk1-in-2.html

Concentration

10mM

Purity

98.34

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

COC1=C(OC)C(OC)=CC(NC2=NC=C(Br)C(OC3=CC=C([N+]([O-])=O)C=C3F)=N2)=C1

Molecular Formula

C19H16BrFN4O6

Molecular Weight

495.26

References & Citations

[1]Sun D, Yang Z, Zhen Y, et al. Discovery of 5-bromo-4-phenoxy-N-phenylpyrimidin-2-amine derivatives as novel ULK1 inhibitors that block autophagy and induce apoptosis in non-small cell lung cancer. Eur J Med Chem. 2020;208:112782.