Thymidine-13C10

Thymidine-13C10 (DThyd-13C10; NSC 21548-13C10) is 13C-labeled Thymidine (HY-N1150) . Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication.

Product Specifications

Product Name Alternative

DThyd-13C10; NSC 21548-13C10

UNSPSC

12352005

Target

DNA/RNA Synthesis; Endogenous Metabolite; Isotope-Labeled Compounds; Orthopoxvirus

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/thymidine-13c10.html

Purity

95.0

Solubility

10 mM in DMSO

Smiles

O=[13C]1[13C]([13CH3])=[13CH]N([13C@@H]2O[13C@H]([13CH2]O)[13C@@H](O)[13CH]2[H])[13C](N1)=O

Molecular Formula

13C10H14N2O5

Molecular Weight

252.16

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Chen G, et al. Cell Synchronization by Double Thymidine Block. Bio Protoc. 2018 Sep 5;8 (17) .|[3]FIRKET H, et al. Autoradiographic visualization of synthesis of deoxyribonucleic acid in tissue culture with tritium-labelled thymidine. Nature. 1958 Jan 24;181 (4604) :274-5.FIRKET H, et al. Autoradiographic visualization of synthesis of deoxyribonucleic acid in tissue culture with tritium-labelled thymidine. Nature. 1958 Jan 24;181 (4604) :274-5.|[4]Izeradjene K, et al. Inhibition of thymidine synthesis by folate analogues induces a Fas-Fas ligand-independentdeletion of superantigen-reactive peripheral T cells. Int Immunol. 2001 Jan;13 (1) :85-93.