MALT1 inhibitor MI-2
MALT1 inhibitor MI-2 is a MALT1 inhibitor (IC50=5.84 μM) . MALT1 inhibitor MI-2 binds directly to MALT1, irreversibly suppresses protease function and is accompanied by NF-κB reporter activity suppression, c-REL nuclear localization inhibition, and NF-κB target gene downregulation. MALT1 inhibitor MI-2 shows nontoxic to animals[1].
Product Specifications
CAS Number
[1047953-91-2]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MALT1
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/MI-2-MALT1-inhibitor.html
Purity
99.73
Solubility
DMSO : ≥ 46 mg/mL
Smiles
O=C(NC1=CC=C(N2N=C(OCCOC)N=C2C3=CC=C(Cl)C(Cl)=C3)C=C1)CCl
Molecular Formula
C19H17Cl3N4O3
Molecular Weight
455.72
Precautions
H302, H315, H319, H335
References & Citations
[1]Fontan L, et al. MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo. Cancer Cell. 2012 Dec 11;22 (6) :812-24.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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