PI3K-IN-2
PI3K-IN-2 (compound 10) is a potent and orally active PI3Kβ/δ (IC50=7.1/8.6 nM) inhibitor with excellent selectivity versus PI3Kσ and PI3Kγ (IC50=13/190 nM, respectively) [1].
Product Specifications
CAS Number
1403458-28-5
UNSPSC
12352005
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pi3k-in-2.html
Purity
99.62
Solubility
10 mM in DMSO
Smiles
O=C1C=C(N2CCOCC2)OC3=C([C@@H]4N(C5=CC(F)=CC(F)=C5)CCC4)C=C(C(N6CCOCC6)=O)C=C13
Molecular Formula
C28H29F2N3O5
Molecular Weight
525.54
References & Citations
[1]Barlaam B, et al. Discovery of a series of 8- (1-phenylpyrrolidin-2-yl) -6-carboxamide-2-morpholino-4H-chromen-4-one as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours. Bioorg Med Chem Lett. 2017 May 1;27 (9) :1949-1954.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
Available Sizes
Frequently Asked Questions
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