PI3K-IN-2

PI3K-IN-2 (compound 10) is a potent and orally active PI3Kβ/δ (IC50=7.1/8.6 nM) inhibitor with excellent selectivity versus PI3Kσ and PI3Kγ (IC50=13/190 nM, respectively) [1].

Product Specifications

CAS Number

[1403458-28-5]

UNSPSC

12352005

Target

PI3K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pi3k-in-2.html

Purity

99.62

Solubility

10 mM in DMSO

Smiles

O=C1C=C(N2CCOCC2)OC3=C([C@@H]4N(C5=CC(F)=CC(F)=C5)CCC4)C=C(C(N6CCOCC6)=O)C=C13

Molecular Formula

C28H29F2N3O5

Molecular Weight

525.54

References & Citations

[1]Barlaam B, et al. Discovery of a series of 8- (1-phenylpyrrolidin-2-yl) -6-carboxamide-2-morpholino-4H-chromen-4-one as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours. Bioorg Med Chem Lett. 2017 May 1;27 (9) :1949-1954.