MSN-50
MSN-50 is a Bax and Bak oligomerization inhibitor. MSN-50 efficiently inhibits liposome permeabilization, prevents genotoxic cell death and promotes neuroprotection[1][2].
Product Specifications
CAS Number
1592908-75-2
Product Name Alternative
KBT 1585 hydrochloride,Tyrphostin B66; AG 528,MSC2363318A
UNSPSC
12352005
Target
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/msn-50.html
Purity
98.68
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=CC=C1)N[C@@H](CC2=CC=CC=C2)C(N(CC3=CC=C(C=C3)Br)C[C@H]4OC5=CC(OCOCCOC)=CC=C5[C@@H]4N)=O
Molecular Formula
C36H38BrN3O6
Molecular Weight
688.61
References & Citations
[1]Niu X, et al. A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection. Cell Chem Biol. 2017;24 (4) :493-506.e5.|[2]Jensen K, et al. Pharmacological inhibition of Bax-induced cell death: Bax-inhibiting peptides and small compounds inhibiting Bax. Exp Biol Med (Maywood) . 2019;244 (8) :621-629.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bak; Bax
Available Sizes
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