MSN-50

MSN-50 is a Bax and Bak oligomerization inhibitor. MSN-50 efficiently inhibits liposome permeabilization, prevents genotoxic cell death and promotes neuroprotection[1][2].

Product Specifications

CAS Number

[1592908-75-2]

Product Name Alternative

KBT 1585 hydrochloride,Tyrphostin B66; AG 528,MSC2363318A

UNSPSC

12352005

Target

Bcl-2 Family

Type

Reference compound

Related Pathways

Apoptosis

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/msn-50.html

Purity

98.68

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=CC=C1)N[C@@H](CC2=CC=CC=C2)C(N(CC3=CC=C(C=C3)Br)C[C@H]4OC5=CC(OCOCCOC)=CC=C5[C@@H]4N)=O

Molecular Formula

C36H38BrN3O6

Molecular Weight

688.61

References & Citations

[1]Niu X, et al. A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection. Cell Chem Biol. 2017;24 (4) :493-506.e5.|[2]Jensen K, et al. Pharmacological inhibition of Bax-induced cell death: Bax-inhibiting peptides and small compounds inhibiting Bax. Exp Biol Med (Maywood) . 2019;244 (8) :621-629.