VBIT-12
VBIT-12 is a potent VDAC1 inhibitor. VBIT-12 directly interacts with VDAC1 and prevents VDAC1 oligomerization, and thus inhibits apoptotic action of VDAC1[1].
Product Specifications
CAS Number
[2089227-65-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
VDAC
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vbit-12.html
Purity
98.87
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(O)CNC(C1(NC2=CC=CC=C2)CCN(CC3=C4C=CC=CC4=CC=C3)CC1)=O
Molecular Formula
C25H27N3O3
Molecular Weight
417.50
Precautions
H302, H315, H319, H335
References & Citations
[1]Shoshan-Barmatz V, et al. VDAC1, mitochondrial dysfunction, and Alzheimer's disease. Pharmacol Res. 2018 May;131:87-101.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
VDAC1
Available Sizes
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