Aloperine

Aloperine is an alkaloid in sophora plants such as Sophora alopecuroides L, which has shown anti-cancer, anti-inflammatory and anti-virus properties[1]. Aloperine is widely used to treat patients with allergic contact dermatitis eczema and other skin inflammation in China[2]. Aloperine induces apoptosis and autophagy in HL-60 cells[1].

Product Specifications

CAS Number

[56293-29-9]

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; Autophagy; Filovirus; HIV

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Autophagy

Applications

Neuroscience-Neurodegeneration

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/aloperine.html

Concentration

10mM

Purity

99.80

Solubility

DMSO : 5.56 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

[H][C@]1(C2)[C@](CCCC3)([H])N3C[C@]2([H])[C@@]4([H])C(CCCN4)=C1

Molecular Formula

C15H24N2

Molecular Weight

232.37

Precautions

H302

References & Citations

[1]Lin Z, et al. In vitro anti-tumour activities of quinolizidine alkaloids derived from Sophora flavescens Ait. Basic Clin Pharmacol Toxicol. 2011 May;108 (5) :304-9.|[2]Yuan XY, et al. Effects and mechanisms of aloperine on 2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice. Eur J Pharmacol. 2010 Mar 10;629 (1-3) :147-52.