γ-Glutamylvaline

γ-Glutamylvaline (γ-Glu-Val) is an activator of CaSR with anti-inflammatory activity. γ-Glutamylvaline inhibits TNF-α-induced proinflammatory cytokine production and increases Wnt5a expression. γ-Glutamylvaline activates calcium-sensing receptor pathways in adipocytes of 3T3-L1 mice and prevents low-grade chronic inflammation[1].

Product Specifications

CAS Number

[2746-34-1]

Product Name Alternative

γ-Glu-Val

UNSPSC

12352209

Target

CaSR; TNF Receptor; Wnt

Type

Natural Products

Related Pathways

Apoptosis; GPCR/G Protein; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/γ-glutamylvaline.html

Purity

99.94

Solubility

H2O : ≥ 100 mg/mL

Smiles

CC([C@@H](C(O)=O)NC(CC[C@H](N)C(O)=O)=O)C

Molecular Formula

C10H18N2O5

Molecular Weight

246.26

References & Citations

[1]Xing L, et al. γ-Glutamylvaline Prevents Low-Grade Chronic Inflammation via Activation of a Calcium-Sensing Receptor Pathway in 3T3-L1Mouse Adipocytes. J Agric Food Chem. 2019 Jul 31;67 (30) :8361-8369.