WNK1 (181-507), Active, GST-tagged Human

<strong>WNK1 (181-507), Active, GST-tagged Human</strong>_x000D_ <strong>Catalog number:</strong> B2019673_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 5 ug_x000D_ <strong>Molecular Weight or Concentration:</strong> ~67 kDa_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> −70°C_x000D_ <strong>Keywords:</strong> HSAN2, HSN2, KDP, KIAA0344, MGC163339, MGC163341, PRKWNK1, PSK, p65_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Wilson PC, Wu H, Kirita Y, Uchimura K, Ledru N, Rennke HG, Welling PA, Waikar SS, Humphreys BD. The single-cell transcriptomic landscape of early human diabetic nephropathy Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19619-19625._x000D_ 2: Bahena-Lopez JP, Gamba G, Castañeda-Bueno M. WNK1 in the kidney Curr Opin Nephrol Hypertens. 2022 Sep 1;31(5):471-478._x000D_ 3: Boyd-Shiwarski CR, Shiwarski DJ, Griffiths SE, Beacham RT, Norrell L, Morrison DE, Wang J, Mann J, Tennant W, Anderson EN, Franks J, Calderon M, Connolly KA, Cheema MU, Weaver CJ, Nkashama LJ, Weckerly CC, Querry KE, Pandey UB, Donnelly CJ, Sun D, Rodan AR, Subramanya AR. WNK kinases sense molecular crowding and rescue cell volume via phase separation Cell. 2022 Nov 23;185(24):4488-4506.e20._x000D_ 4: Quelquejay H, Al-Rifai R, Silvestro M, Vandestienne M, Ferreira I, Mirault T, Henrion D, Zhong X, Santos-Zas I, Goudot G, Alayrac P, Robidel E, Autret G, Balvay D, Taleb S, Tedgui A, Boulanger CM, Zernecke A, Saliba AE, Hadchouel J, Ramkhelawon B, Cochain C, Bergaya S, Jeunemaitre X, Ait-Oufella H. L-Wnk1 Deletion in Smooth Muscle Cells Causes Aortitis and Inflammatory Shift Circ Res. 2024 Aug 2;135(4):488-502._x000D_ 5: Li L, Xie D, Yu S, Ma M, Fan K, Chen J, Xiu M, Xie K, Li Y, Gao Y. WNK1 Interaction with KEAP1 Promotes NRF2 Stabilization to Enhance the Oxidative Stress Response in Hepatocellular Carcinoma Cancer Res. 2024 Sep 4;84(17):2776-2791._x000D_ 6: Jung JU, Cobb MH. WNK1 controls endosomal trafficking through TRIM27-dependent regulation of actin assembly Proc Natl Acad Sci U S A. 2023 Jun 20;120(25):e2300310120._x000D_ 7: Cheng JC, Meng Q, Zhang Q, Zhang L, Chen J, Song T, Fang L, Sun YP. WNK1 mediates amphiregulin-induced MMP9 expression and cell invasion in human extravillous trophoblast cells Mol Cell Endocrinol. 2023 Oct 1;576:112038._x000D_ 8: Bakouh N, Castaño-Martín R, Metais A, Dan EL, Balducci E, Chhuon C, Lepicka J, Barcia G, Losito E, Lourdel S, Planelles G, Muresan RC, Moca VV, Kaminska A, Bourgeois M, Chemaly N, Rguez Y, Auvin S, Huberfeld G, Varlet P, Asnafi V, Guerrera IC, Kabashi E, Nabbout R, Ciura S, Blauwblomme T. Chloride deregulation and GABA depolarization in MTOR related malformations of cortical development Brain. 2024 Aug 6:awae262._x000D_ 9: Gallolu Kankanamalage S, Lee AY, Wichaidit C, Lorente-Rodriguez A, Shah AM, Stippec S, Whitehurst AW, Cobb MH. WNK1 is an unexpected autophagy inhibitor Autophagy. 2017 May 4;13(5):969-970._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/38722741">10: Ye T, Mishra AK, Banday S, Li R, Hu K, Coleman MM, Shan Y, Chowdhury SR, Zhou L, Pak ML, Simone TM, Malonia SK, Zhu LJ, Kelliher MA, Green MR. Identification of WNK1 as a therapeutic target to suppress IgH/MYC expression in multiple myeloma Cell Rep. 2024 May 28;43(5):114211. </a>_x000D_ _x000D_ <strong>Products Related to WNK1 (181-507), Active, GST-tagged Human can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>