5-Aza-4'-thio-2'-deoxycytidine

5-Aza-4'-thio-2'-deoxycytidine (5-Aza-T-dCyd) is an orally active DNA methyltransferase I (DNMT1) inhibitor. 5-Aza-4'-thio-2'-deoxycytidine, a sulfur-containing deoxy-cytidine analog, has the potential for DNA hypomethylating and has antitumor effects[1].

Product Specifications

CAS Number

[169514-76-5]

Product Name Alternative

5-Aza-T-dCyd; NTX-301

UNSPSC

12352005

Target

DNA Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/5-aza-4-thio-2-deoxycytidine.html

Purity

99.09

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O[C@H]1C[C@H](N(C=N2)C(N=C2N)=O)S[C@@H]1CO

Molecular Formula

C8H12N4O3S

Molecular Weight

244.27

References & Citations

[1]Jaideep V Thottassery, et al. Novel DNA methyltransferase-1 (DNMT1) depleting anticancer nucleosides, 4'-thio-2'-deoxycytidine and 5-aza-4'-thio-2'-deoxycytidine. Cancer Chemother Pharmacol. 2014 Aug;74 (2) :291-302.|[2]Joel Morris, et al. F-aza-T-dCyd (NSC801845), a Novel Cytidine Analog, in Comparative Cell Culture and Xenograft Studies with the Clinical Candidates T-dCyd, F-T-dCyd, and Aza-T-dCyd. Mol Cancer Ther. 2021 Apr;20 (4) :625-631.