BMS-816336
BMS-816336 is a novel, potent and orally bioavailable inhibitor against human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme with an IC50 of 3.0 nM[1].
Product Specifications
CAS Number
1009583-20-3
UNSPSC
12352005
Target
11β-HSD
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/BMS-816336.html
Purity
99.86
Solubility
DMSO : 300 mg/mL (ultrasonic)
Smiles
O[C@@H]1[C@H]2C[C@@H]3[C@@](C4=CC=CC=C4)(CC(N5CC(O)C5)=O)[C@@H](C[C@H]1C3)C2
Molecular Formula
C21H27NO3
Molecular Weight
341.44
References & Citations
[1]Ye XY, et al. Discovery of Clinical Candidate 2- ((2S,6S) -2-Phenyl-6-hydroxyadamantan-2-yl) -1- (3'-hydroxyazetidin-1-yl) ethanone [BMS-816336], an Orally Active Novel Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor. J Med Chem. 2017 Jun 22;60 (12) :4932-4948.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
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