Atorvastatin (hemicalcium salt) (Standard)

Atorvastatin (hemicalcium salt) (Standard) is the analytical standard of Atorvastatin (hemicalcium salt) . This product is intended for research and analytical applications. Atorvastatin hemicalcium salt (CI-981) is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin hemicalcium salt inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively[1][2][3].

Product Specifications

CAS Number

[134523-03-8]

Product Name Alternative

CI-981 (Standard) ; Atorvastatin hemicalcium (Standard)

UNSPSC

12352005

Hazard Statement

H373-H402-H411

Target

Autophagy; Ferroptosis; HMG-CoA Reductase (HMGCR) ; Reference Standards

Type

Reference Standards

Related Pathways

Apoptosis; Autophagy; Metabolic Enzyme/Protease; Others

Field of Research

Metabolic Disease; Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/atorvastatin-hemicalcium-salt-standard.html

Purity

99.64

Smiles

FC1=CC=C(C2=C(C3=CC=CC=C3)C(C(NC4=CC=CC=C4)=O)=C(C(C)C)N2CC[C@@H](O)C[C@@H](O)CC([O-])=O)C=C1.[0.5Ca2+]

Molecular Formula

C33H34CaFN2O5-

Molecular Weight

577.67

Precautions

P260-P273-P391-P501

References & Citations

[1]Santodomingo-Garzón T, et al. Atorvastatin inhibits inflammatory hypernociception. Br J Pharmacol. 2006 Sep;149 (1) :14-22.|[2]Turner NA, et al. Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J Cardiovasc Pharmacol. 2007 Oct;50 (4) :458-61.|[3]Nawrocki, J.W., et al., Reduction of LDL cholesterol by 25% to 60% in patients with primary hypercholesterolemia by atorvastatin, a new HMG-CoA reductase inhibitor. Arterioscler Thromb Vasc Biol, 1995. 15 (5) : p. 678-82.|[4]Song XJ, et al. Atorvastatin inhibits myocardial cell apoptosis in a rat model with post-myocardial infarction heart failure by downregulating ER stress response. Int J Med Sci. 2011;8 (7) :564-72.|[5] Li Y, et al. Inhibition of endoplasmic reticulum stress signaling pathway: A new mechanism of statins to suppress the development of abdominal aortic aneurysm. PLoS One. 2017 Apr 3;12 (4) :e0174821.