(±)-BI-D
Product Specifications
UNSPSC Description
(±)-BI-D is an allosteric inhibitor of HIV integrase, acting on the binding site between integrase and LEDGF/p75.
Target Antigen
HIV; HIV Integrase
Type
Reference compound
Related Pathways
Anti-infection;Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/__plusmn__-BI-D.html
Purity
98.06
Solubility
DMSO : ≥ 100 mg/mL
Smiles
OC(C(OC(C)(C)C)C1=C(C(C=CC=C2)=C2N=C1C)C3=CC(CCCO4)=C4C=C3)=O
Molecular Weight
405.49
References & Citations
[1]Wang H, et al. HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor. Nucleic Acids Res. 2012 Dec;40(22):11518-30.|[2]Fader LD, et al. Minimizing the Contribution of Enterohepatic Recirculation to Clearance in Rat for the NCINI Class of Inhibitors of HIV. ACS Med Chem Lett. 2014 Apr 16;5(6):711-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-18601/racemic-BI-D-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-18601/racemic-BI-D-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1416258-16-6
Available Sizes
Curated Selection
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