B-Raf IN 11
B-Raf IN 11 (ZINC72115182) is a selective B-RafV600E inhibitor (IC50=76 nM), shows selectivity for B-RafV600E over B-RafWT with selectivity of 3.1-fold. B-Raf IN 11 can be used in colorectal cancer research[1]
Product Specifications
CAS Number
[918504-27-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Raf
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/b-raf-in-11.html
Concentration
10mM
Purity
99.46
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC1=C(C(C2=CNC3=NC=C(Br)C=C32)=O)C(F)=C(NS(=O)(CCC)=O)C=C1
Molecular Formula
C17H14BrF2N3O3S
Molecular Weight
458.28
Precautions
H302, H315, H319, H335
References & Citations
[1]Yao H, et al. Identification and Characterization of Small-Molecule Inhibitors to Selectively Target the DFG-in over the DFG-out Conformation of the B-Raf Kinase V600E Mutant in Colorectal Cancer. Arch Pharm (Weinheim) . 2016 Oct;349 (10) :808-815.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
B-Raf
Available Sizes
Curated Selection
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