B-Raf IN 11
Product Specifications
UNSPSC Description
B-Raf IN 11 (ZINC72115182) is a selective B-RafV600E inhibitor (IC50=76 nM), shows selectivity for
B-RafV600E over B-RafWT with selectivity of 3.1-fold. B-Raf IN 11 can be used in colorectal cancer research[1]
Target Antigen
Raf
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/b-raf-in-11.html
Purity
99.55
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC1=C(C(C2=CNC3=NC=C(Br)C=C32)=O)C(F)=C(NS(=O)(CCC)=O)C=C1
Molecular Weight
458.284
References & Citations
[1]Yao H, et al. Identification and Characterization of Small-Molecule Inhibitors to Selectively Target the DFG-in over the DFG-out Conformation of the B-Raf Kinase V600E Mutant in Colorectal Cancer. Arch Pharm (Weinheim). 2016 Oct;349(10):808-815.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-77113/B-Raf-IN-11-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-77113/B-Raf-IN-11-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
918504-27-5
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![S100A9 Mouse Monoclonal Antibody [Clone:10D5]](https://cdn.genprice.uk/genprice/genprice5.png)
MBS1032101-01 0.02 mg (E-Coli)
Recombinant Loxosceles hirsuta Sphingomyelin phosphodiesterase D LhSicTox-alphaIA2biii
Ask
View Details 
MBS1032101-02 0.02 mg (Yeast)
Recombinant Loxosceles hirsuta Sphingomyelin phosphodiesterase D LhSicTox-alphaIA2biii
Ask
View Details MBS1032101-03 0.1 mg (E-Coli)
Recombinant Loxosceles hirsuta Sphingomyelin phosphodiesterase D LhSicTox-alphaIA2biii
Ask
View Details