L-745870 (hydrochloride)
L-745870 hydrochloride is a potent, selective, brain-penetrant and orally active dopamine D4 receptor antagonist with a Ki of 0.43 nM. L-745870 hydrochloride shows weaker affinity for D2 (Ki of 960 nM) and D3 (Ki of 2300 nM) receptors, and exhibits moderate affinity for 5-HT2 receptors, sigma sites and α-adrenoceptors[1][2][3].
Product Specifications
CAS Number
1173023-36-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/l-745870-hydrochloride.html
Purity
99.91
Solubility
0.1 M HCl : 25 mg/mL (ultrasonic; adjust pH to 3 with HCl) |DMSO : 32.26 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL
Smiles
[H]Cl.ClC(C=C1)=CC=C1N(CC2)CCN2CC3=CNC4=NC=CC=C43
Molecular Formula
C18H20Cl2N4
Molecular Weight
363.28
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D2 Receptor; D3 Receptor; D4 Receptor
Citation 01
Psychopharmacology (Berl) . 2022 Nov;239 (11) :3551-3565.|Br J Cancer. 2024 Oct;131 (7) :1212-1223.|Research Square Preprint. 2023 Oct 3.
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