3-Phenyltoxoflavin

3-Phenyltoxoflavin, a derivative of Toxoflavin, is an Hsp90 inhibitor, with a Kd of 585 nM for the interaction of Hsp90-TPR2A. 3-Phenyltoxoflavin has anti-cancer activity[1][2].

Product Specifications

CAS Number

[32502-63-9]

UNSPSC

12352005

Hazard Statement

H301, H315, H319, H335

Target

HSP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/3-phenyltoxoflavin.html

Purity

99.76

Solubility

DMSO : 7.14 mg/mL (ultrasonic)

Smiles

O=C(C1=NC(C2=CC=CC=C2)=NN(C)C1=N3)N(C)C3=O

Molecular Formula

C13H11N5O2

Molecular Weight

269.26

Precautions

H301, H315, H319, H335

References & Citations

[1]Yi F, et, al. A novel class of small molecule inhibitors of Hsp90. ACS Chem Biol. 2008 Oct 17;3 (10) :645-54.|[2]Koh S, et, al. A novel light-dependent selection marker system in plants. Plant Biotechnol J. 2011 Apr;9 (3) :348-58.