L-Naproxen

L-Naproxen ((R) -Naproxen) is an enantiomer of (S) -Naproxen. l-Naproxen can inhibit Cdc42 and Rac1 (EC50=96 μM and 212 μM, respectively), and show anti-tumor activity. l-Naproxen is a nonsteroidal antiinflammatory agent (NSAID) [1][2][3].

Product Specifications

CAS Number

[23979-41-1]

Product Name Alternative

(R) -Naproxen

UNSPSC

12352005

Hazard Statement

H302

Target

Ras

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/l-naproxen.html

Concentration

10mM

Purity

99.88

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=CC=C2C(C=CC([C@H](C(O)=O)C)=C2)=C1

Molecular Formula

C14H14O3

Molecular Weight

230.26

Precautions

H302

References & Citations

[1]Sonika Batra, et al. Enantiomeric Resolution of (RS) -Naproxen and Application of (S) - Naproxen in the Direct and Indirect Enantioseparation of Racemic Compounds by Liquid Chromatography: A Review. Curr Med Chem. 2017;24 (8) :758-780.|[2]M Iwaki, et al. Stereoselective disposition of naproxen glucuronide in the rat. Drug Metab Dispos. 1995 Oct;23 (10) :1099-103.|[3]Tudor I Oprea, et al. Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases. PLoS One. 2015 Nov 11;10 (11) :e0142182.