4-Acetamidophenyl acetate

4-Acetamidophenyl acetate is an impurity of Acetaminophen (HY-66005) . 4-Acetamidophenyl acetate acts as an intermediate in the synthesis of Acetaminophen. Acetaminophen is a selective COX-2 inhibitor (IC50=25.8 μM), and is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[1][2][3].

Product Specifications

CAS Number

[2623-33-8]

Product Name Alternative

Diacetamate

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial; Drug Intermediate; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/4-acetamidophenyl-acetate.html

Purity

97.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C)NC1=CC=C(OC(C)=O)C=C1

Molecular Formula

C10H11NO3

Molecular Weight

193.20

Precautions

H302, H315, H319, H335

References & Citations

[1]Hinz, B, et al. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J, 2008. 22 (2) : p. 383-90.|[2]Rothen JP, et al. Acetaminophen is an inhibitor of hepatic N-acetyltransferase 2 in vitro and in vivo. Pharmacogenetics. 1998 Dec;8 (6) :553-9.|[3]Murie V E, et al. Acetaminophen prodrug: microwave-assisted synthesis and in vitro metabolism evaluation by mass spectrometry. Journal of the Brazilian Chemical Society, 2016, 27 (6) : 1121-1128.