PD-1/PD-L1-IN-43

PD-1/PD-L1-IN-43 (compound Z13) is a small-molecule inhibitors targeting the PD-1/PD-L1 interaction. PD-1/PD-L1-IN-43 exhibites potent in vivo antitumor efficacy against B16-F10 melanoma. PD-1/PD-L1-IN-43 inhibits tumor growth by blocking the interaction between PD-1 and PD-L1. PD-1/PD-L1-IN-43 can be used in anti-tumor studies[1].

Product Specifications

UNSPSC

12352005

Target

PD-1/PD-L1

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pd-1-pd-l1-in-43.html

Solubility

10 mM in DMSO

Smiles

O=C(N1N=CC2=C1C=CC=C2C3=CC=C4OCCOC4=C3)C5=CC=C(C=C5)CN6CC[C@H](C6)O

Molecular Formula

C27H25N3O4

Molecular Weight

455.51

References & Citations

[1]Xu C, et al. Discovery of 4-phenyl-1H-indazole derivatives as novel small-molecule inhibitors targeting the PD-1/PD-L1 interaction[J]. Bioorganic Chemistry, 2024: 107376.