Lactyl-CoA

Lactyl-CoA is an acyl-CoA formally condensed from the sulfhydryl group of CoA and the carboxyl group of lactic acid, also known as lactyl-CoA. Lactyl-CoA is essential for the biosynthesis of biodegradable and biocompatible lactic acid-based copolymers[1][2].

Product Specifications

CAS Number

[1926-57-4]

UNSPSC

12352005

Target

Biochemical Assay Reagents; Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/lactyl-coa.html

Purity

98.01

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL

Smiles

O[C@H]1[C@](O[C@@H]([C@H]1OP(O)(O)=O)COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(C(O)C)=O)=O)=O)(O)=O)(O)=O)([H])N2C3=NC=NC(N)=C3N=C2

Molecular Formula

C24H40N7O18P3S

Molecular Weight

839.60

References & Citations

[1]Xiaoxia Zhang, et al. Screening, expression, purification and characterization of CoA-transferases for lactoyl-CoA generation. J Ind Microbiol Biotechnol. 2019 Jul;46 (7) :899-909. |[2]Liu R, et al. Nuclear GTPSCS functions as a lactyl-CoA synthetase to promote histone lactylation and gliomagenesis. Cell Metab. 2025 Feb 4;37 (2) :377-394.e9.