Piperine
Product Specifications
UNSPSC Description
Piperine is an alkaloid, can be isolated from pepper. Piperine can inhibit the activity of P-glycoprotein and CYP3A4. Piperine inhibits HeLa cells with an IC50 of 61.94±0.054 μg/mL[1][2][3].
Target Antigen
Autophagy; Endogenous Metabolite; P-glycoprotein
Type
Natural Products
Related Pathways
Autophagy;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/Piperine.html
Purity
98.94
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N1CCCCC1)/C=C/C=C/C2=CC=C(OCO3)C3=C2
Molecular Weight
285.34
References & Citations
[1]Paarakh PM, et al. In vitro cytotoxic and in silico activity of piperine isolated from Piper nigrum fruits Linn. In Silico Pharmacol. 2015 Dec;3(1):9. Epub 2015 Oct 29.|[2]Meghwal M,et al. Piper nigrum and piperine: an update. Phytother Res. 2013 Aug;27(8):1121-30.|[3]Li C, et al. Non-linear pharmacokinetics of piperine and its herb-drug interactions with docetaxel in Sprague-Dawley rats. J Pharm Biomed Anal. 2016 Sep 5;128:286-93.|[4]Zhai WJ, et al. Piperine Plays an Anti-Inflammatory Role in Staphylococcus aureus Endometritis by Inhibiting Activation of NF-κB and MAPK Pathways in Mice. Evid Based Complement Alternat Med. 2016;2016:8597208.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N0144/Piperine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N0144/Piperine-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
94-62-2
Available Sizes
Curated Selection
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