Piperine

Piperine is an alkaloid, can be isolated from pepper. Piperine can inhibit the activity of P-glycoprotein and CYP3A4. Piperine inhibits HeLa cells with an IC50 of 61.94±0.054 μg/mL[1][2][3].

Product Specifications

CAS Number

[94-62-2]

Product Name Alternative

Bioperine; 1-Piperoylpiperidine

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; Endogenous Metabolite; P-glycoprotein

Type

Natural Products

Related Pathways

Autophagy; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/Piperine.html

Purity

98.99

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(N1CCCCC1)/C=C/C=C/C2=CC=C(OCO3)C3=C2

Molecular Formula

C17H19NO3

Molecular Weight

285.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Paarakh PM, et al. In vitro cytotoxic and in silico activity of piperine isolated from Piper nigrum fruits Linn. In Silico Pharmacol. 2015 Dec;3 (1) :9. Epub 2015 Oct 29.|[2]Meghwal M, et al. Piper nigrum and piperine: an update. Phytother Res. 2013 Aug;27 (8) :1121-30.|[3]Li C, et al. Non-linear pharmacokinetics of piperine and its herb-drug interactions with docetaxel in Sprague-Dawley rats. J Pharm Biomed Anal. 2016 Sep 5;128:286-93.|[4]Zhai WJ, et al. Piperine Plays an Anti-Inflammatory Role in Staphylococcus aureus Endometritis by Inhibiting Activation of NF-κB and MAPK Pathways in Mice. Evid Based Complement Alternat Med. 2016;2016:8597208.