What is the catalog number for GsMTx4?

The catalog number for GsMTx4 is HY-P1410.

What sizes are available for GsMTx4?

GsMTx4 is available in the following size(s): 500 µg, 1 mg, 5 mg.

How many pack sizes does GsMTx4 come in?

GsMTx4 is available in 3 different pack sizes.

GsMTx4 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures GsMTx4?

GsMTx4 is manufactured by QuantiMol.

What is the estimated delivery time for GsMTx4?

Estimated delivery time for GsMTx4 is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for GsMTx4?

The safety data sheet for GsMTx4 is available here: http://file.medchemexpress.com/batch_PDF/HY-P1410/GsMTx4-SDS-MedChemExpress.pdf.

Can this product be used in multiplex assays?

Multiplex compatibility depends on the specific product and detection panel. Contact our technical support team with details of your multiplex system for guidance before ordering.

What happens if this product doesn’t perform as expected in my experiment?

Send us the catalogue number, product name, lot number, and a summary of your results. Our technical support team will investigate and, where needed, involve the manufacturer. This is covered under our guarantee provided the product was used before its expiry date and stored correctly.

Is this product classed as hazardous or restricted for shipping?

Some products are subject to special import/export regulations, dangerous goods handling, or licensing requirements. Where this applies, it’s noted on the product page, and any required extra documents or fees will be confirmed with you before dispatch, never added without your consent.

GsMTx4

GsMTx4 is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 also blocks cation-selective stretch-activated channels (SACs), attenuates lysophosphatidylcholine (LPC) -induced astrocyte toxicity and microglial reactivity. GsMTx4 is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology[1][2][4].

Product Specifications

CAS Number

1209500-46-8

UNSPSC

12352209

Target

Piezo Channel; TRP Channel

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/gsmtx4.html

Purity

99.83

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCNC(N)=N)C(N1[C@@H](CCC1)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@H]2CCCCN)=O)=O)=O)=O)=O)NC3=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CC5=CNC6=CC=CC=C56)C(N[C@@H](CC7=CNC8=CC=CC=C78)C(N[C@@H](CCCCN)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC9=CC=CC=C9)C(N[C@@H](CCCCN)C(N[C@H]%10CC(C)C)=O)=O)=O)=O)=O)=O)NC2=O)C(N[C@@H](CC(N)=O)C(N%11[C@@H](CCC%11)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@H]3CSSC[C@@H](C(N[C@@H](CC(N)=O)C(N[C@@H](CC%12=CC=CC=C%12)C(N[C@@H](CO)C(N[C@@H](CC%13=CC=CC=C%13)C(N)=O)=O)=O)=O)=O)NC%10=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN

Molecular Formula

C185H273N49O45S6

Molecular Weight

4095.84

References & Citations

[1]Gnanasambandam R, et al. GsMTx4: Mechanism of Inhibiting Mechanosensitive Ion Channels. Biophys J. 2017 Jan 10;112 (1) :31-45. |[2]T M Suchyna, et al. Identification of a peptide toxin from Grammostola spatulata spider venom that blocks cation-selective stretch-activated channels. J Gen Physiol. 2000 May;115 (5) :583-98. |[3]Anna Acheva, et al. Adipokine Leptin Co-operates With Mechanosensitive Ca 2 +-Channels and Triggers Actomyosin-Mediated Motility of Breast Epithelial Cells. Front Cell Dev Biol. 2021 Jan 6;8:607038. |[4]María Velasco-Estevez, et al. Inhibition of Piezo1 attenuates demyelination in the central nervous system. Glia. 2020 Feb;68 (2) :356-375. |[5]Medha M Pathak, et al. Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells. Proc Natl Acad Sci U S A. 2014 Nov 11;111 (45) :16148-53.|[6]Seung Pyo Park, et al. A tarantula spider toxin, GsMTx4, reduces mechanical and neuropathic pain. Pain. 2008 Jul;137 (1) :208-217.