Autogramin-2
Autogramin-2 potently inhibits autophagy induced by either starvation (IC50=0.27 μM) or mTORC1 inhibition (Rapamycin; IC50=0.14 μM) [1].
Product Specifications
CAS Number
[2375541-45-8]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy
Type
Reference compound
Related Pathways
Autophagy
Applications
COVID-19-immunoregulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/autogramin-2.html
Purity
99.20
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=C(NC1=NC(CCN(C(OC(C)(C)C)=O)C2)=C2S1)C3=CC=C(OC(C)C)C=C3
Molecular Formula
C21H27N3O4S
Molecular Weight
417.52
Precautions
H302, H315, H319, H335
References & Citations
[1]Laraia L, et al. The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis. Nat Chem Biol. 2019 Jul;15 (7) :710-720.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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