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Mabuterol

Mabuterol is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB[1][2].

Product Specifications

CAS Number

56341-08-3

UNSPSC

12352005

Hazard Statement

H301

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/mabuterol.html

Purity

99.96

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

CC(NCC(O)C1=CC(C(F)(F)F)=C(N)C(Cl)=C1)(C)C

Molecular Formula

C13H18ClF3N2O

Molecular Weight

310.74

Precautions

H301

References & Citations

[1]Yamamoto I, et al. Enzyme immunoassay for mabuterol, a selective beta 2-adrenergic stimulant in the trachea. J Immunoassay. 1985;6 (3) :261-76. |[2]Yaru Gu, et al. Inhibitory effect of mabuterol on proliferation of rat ASMCs induced by PDGF-BB via regulating [Ca2+]i and mitochondrial fission/fusion. Interactions, 2019, 307: 63-72.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

β adrenergic receptor

Available Sizes

Frequently Asked Questions

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