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Recombinant Human Collagen alpha-1 protein (COL15A1) (Active)

Product Specifications

Background

Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle. {ECO:0000269|PubMed:10049780}.; Restin potently inhibits angiogenesis. {ECO:0000250}.

Product Name Alternative

XV, Related to endostatin, Restin-I, ; Restin-2 Restin-II, ; Restin-3 Restin-III

Gene ID

1306

UniProt

P39059

Target

NYEKPALHLA ALNMPFSGDI RADFQCFKQA RAAGLLSTYR AFLSSHLQDL STIVRKAERY SLPIVNLKGQ VLFNNWDSIF SGHGGQFNMH IPIYSFDGRD IMTDPSWPQK VIWHGSSPHG VRLVDNYCEA WRTADTAVTG LASPLSTGKI LDQKAYSCAN RLIVLCIENS FMTDARK

Purification

>96% as determined by SDS-PAGE and HPLC.

Bioactivity

Fully biologically active when compared to standard. The ED50 as determined by inhibiting the FGF basic-dependent proliferation of HUVEC migration is less than 2.0 ?g, mL in the presence of Anti- Human Endostatin Polyclonal Antibody.

Storage Conditions

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Calculated Molecular Weight

19.8 kDa

Formulation

0.2 μ m filtered PBS, pH 7.4 , lyophilized

Host or Source

E.Coli

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