EIF2α activator 2
Product Specifications
UNSPSC Description
EIF2α activator 2 (Compound 1) is an activator of eukaryotic initiation factor 2 alpha (eIF2α) phosphorylation. EIF2α activator 2 exhibits high potency in SRB cell proliferation assays (IC50=0.46 μM). EIF2α activator 2 exhibits antiproliferative activity againist K562 and PBMC cells with IC50s of 4.79 and 10.52 μM, respectively[1].
Target Antigen
Eukaryotic Initiation Factor (eIF)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/eif2α-activator-2.html
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
FC(F)(F)C(C=C1)=CC=C1O[C@H](CC2)CC[C@@H]2NC(NC3=CC(C(F)(F)F)=CC=C3)=O
Molecular Weight
446.39
References & Citations
[1]Jinsook Kwak, et al. A bioisosteric approach to the discovery of novel N-aryl-N'-[4-(aryloxy)cyclohexyl]squaramide-based activators of eukaryotic initiation factor 2 alpha (eIF2α) phosphorylation. Eur J Med Chem. 2022 May 29;239:114501.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-147832/EIF2α-activator-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-147832/EIF2α-activator-2-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1501618-04-7
Available Sizes
Curated Selection
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