EIF2α activator 2

EIF2α activator 2 (Compound 1) is an activator of eukaryotic initiation factor 2 alpha (eIF2α) phosphorylation. EIF2α activator 2 exhibits high potency in SRB cell proliferation assays (IC50=0.46 μM) . EIF2α activator 2 exhibits antiproliferative activity againist K562 and PBMC cells with IC50s of 4.79 and 10.52 μM, respectively[1].

Product Specifications

CAS Number

[1501618-04-7]

UNSPSC

12352005

Target

Eukaryotic Initiation Factor (eIF)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/eif2α-activator-2.html

Concentration

10mM

Purity

99.57

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

FC(F)(F)C(C=C1)=CC=C1O[C@H](CC2)CC[C@@H]2NC(NC3=CC(C(F)(F)F)=CC=C3)=O

Molecular Formula

C21H20F6N2O2

Molecular Weight

446.39

References & Citations

[1]Jinsook Kwak, et al. A bioisosteric approach to the discovery of novel N-aryl-N'-[4- (aryloxy) cyclohexyl]squaramide-based activators of eukaryotic initiation factor 2 alpha (eIF2α) phosphorylation. Eur J Med Chem. 2022 May 29;239:114501.