Napabucasin
Napabucasin (BBI608) is a STAT3 inhibitor which blocks stem cell activity in cancer cells.
Product Specifications
CAS Number
83280-65-3
Product Name Alternative
BBI608
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
STAT
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Napabucasin.html
Purity
99.94
Solubility
DMSO : 4.44 mg/mL (ultrasonic) |Ethanol : < 1 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL|N-Methylpyrrolidone (NMP) : 16.67 mg/mL (ultrasonic)
Smiles
O=C(C1=C2OC(C(C)=O)=C1)C3=C(C2=O)C=CC=C3
Molecular Formula
C14H8O4
Molecular Weight
240.21
Precautions
H315, H319, H335
References & Citations
[1]Zhang Y, et al. Suppression of prostate cancer progression by cancer cell stemness inhibitor napabucasin. Cancer Med. 2016 Jun;5 (6) :1251-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
STAT3
Available Sizes
Frequently Asked Questions
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