Napabucasin

Napabucasin (BBI608) is a STAT3 inhibitor which blocks stem cell activity in cancer cells.

Product Specifications

CAS Number

[83280-65-3]

Product Name Alternative

BBI608

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

STAT

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Napabucasin.html

Purity

99.94

Solubility

DMSO : 4.44 mg/mL (ultrasonic) |Ethanol : < 1 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL|N-Methylpyrrolidone (NMP) : 16.67 mg/mL (ultrasonic)

Smiles

O=C(C1=C2OC(C(C)=O)=C1)C3=C(C2=O)C=CC=C3

Molecular Formula

C14H8O4

Molecular Weight

240.21

Precautions

H315, H319, H335

References & Citations

[1]Zhang Y, et al. Suppression of prostate cancer progression by cancer cell stemness inhibitor napabucasin. Cancer Med. 2016 Jun;5 (6) :1251-8.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 3

Isoform

STAT3

Available Sizes

Curated Selection

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