What is the catalog number for Spermine?

The catalog number for Spermine is HY-B1777.

What sizes are available for Spermine?

Spermine is available in the following size(s): 100 mg, 10 mM - 1 mL, 500 mg, 1 g, 5 g.

How many pack sizes does Spermine come in?

Spermine is available in 5 different pack sizes.

Is Spermine in stock?

Spermine is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Spermine?

Spermine is manufactured by QuantiMol.

What is the estimated delivery time for Spermine?

Estimated delivery time for Spermine is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Spermine?

The safety data sheet for Spermine is available here: http://file.medchemexpress.com/batch_PDF/HY-B1777/Spermine-SDS-MedChemExpress.pdf.

Spermine

Spermine is a natural antioxidant and anti-inflammatory agent. Spermine is known to inhibit some bacterial cultures, especially strains of Staphylococcus aureus. Spermine induces neurotoxicity in the striarum dose-dependently. Spermine can reversibly inhibits DNA synthetic response, mixed lymphocyte response and the induction of cytolytic lymphocyte response in primary cultures of murine spleen cells. Spermine tetrahydrochloride is a polyamine nitric oxide donor that can provide nitric oxide to platelets and inhibit platelet activation to a certain extent concentration-dependently. Spermine tetrahydrochloride occurs in mammalian tissues, plants, bacteria, ribosomes and bacteriophage. Spermine tetrahydrochloride inhibits primary human embryo lung fibroblasts in vitro[1][2][3][4][5][6].

Product Specifications

CAS Number

71-44-3

Product Name Alternative

NSC 268508; Neuridine

UNSPSC

12352211

Hazard Statement

H314

Target

Bacterial; DNA/RNA Synthesis; Endogenous Metabolite; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Spermine.html

Purity

99.81

Solubility

H2O : ≥ 200 mg/mL

Smiles

NCCCNCCCCNCCCN

Molecular Formula

C10H26N4

Molecular Weight

202.34

Precautions

H314

References & Citations

[1]U. Bachrach & B. Reches, (1966) Enzymic assay for spermine and spermidine, Analytical Biochemistry, Volume 17, Issue 1, Volume 17, Issue 1, ISSN 0003-2697.|[2]Dawson, M., & Dryden, W. F. (1969) . The toxicity of spermine and spermidine to cells in culture. Biochemical pharmacology, 18 (6), 1307–1313.|[3]Byrd, W. J., et al., (1977) . Synthetic polyamines added to cultures containing bovine sera reversibly inhibit in vitro parameters of immunity. Nature, 267 (5612), 621–623.|[4]Løvaas, E., & Carlin, G. (1991) . Spermine: an anti-oxidant and anti-inflammatory agent. Free radical biology & medicine, 11 (5), 455–461.|[5]WANG Jing, et al., (2022) Preliminary Study on Spermine Tetrahydrochloride Inhibition of Platelet Activation[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2022, 24 (3) : 315-319.|[6]Otsuki, M., et al., (1995) . In vivo pharmacological study of spermine-induced neurotoxicity. Neuroscience letters, 196 (1-2), 81–84.