Cadherin 2 Antibody / CDH2
Recognizes a protein of ~140kDa, identified as N-Cadherin (NCAD), also known as CD325. NCAD is a member of the Cadherin superfamily, and consists of five extracellular repeats, a transmembrane domain and a cytoplasmic domain. CD325 deficient mice die at day 10 of gestation and embryos display major heart defects and malformed neural tubes and somites. Consistent with this, CD325 has been implicated in several aspects of cardiac development including the precardiac mesoderm, establishment of left-right symmetry and cardiac looping morphogenesis. Furthermore, CD325 is normally involved in inducing cell cycle arrest and its expression is frequently deregulated in cancer cells.
Product Specifications
UniProt
P19022
Reactivity
Human
Immunogen
A portion of amino acids 400-600 from human Cadherin 2 protein was used as the immunogen for the Cadherin 2 antibody.
Clonality
Monoclonal
Clone
CDH2/9494
Conjugation
Unconjugated
Field of Research
Immunology & Inflammation
Purification
Protein G affinity
Dilution
Immunohistochemistry (FFPE) : 1-2ug/ml, Western blot: 1-2ug/ml
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the Cadherin 2 antibody should be determined by the researcher.
Tested Applications
IHC-P, WB
Host or Source
Mouse
Preservative
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin, 0.05% sodium azide
Isotype
Mouse IgG2b, kappa
Available Sizes
Frequently Asked Questions
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