SNC80

SNC80 (NIH 10815) is a potent, highly selective and non-peptide δ-opioid receptor agonist with a Ki of 1.78 nM and an IC50 of 2.73 nM. SNC80 also selectively activates μ-δ heteromer in HEK293 cells with an EC50 of 52.8 nM. SNC80 shows antinociceptive, antihyperalgesic and antidepressant‐like effects. SNC80 has the potential for multiple headache disorders treatment[1][2][3][4][5][6].

Product Specifications

CAS Number

[156727-74-1]

Product Name Alternative

NIH 10815

UNSPSC

12352005

Target

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/snc80.html

Purity

99.82

Solubility

1 M HCl : 10 mg/mL (ultrasonic; warming; heat to 60°C) |DMSO : 33.33 mg/mL (ultrasonic; adjust pH to 3 with HCl)

Smiles

O=C(N(CC)CC)C1=CC=C([C@@H](N2[C@@H](C)CN(CC=C)[C@H](C)C2)C3=CC=CC(OC)=C3)C=C1

Molecular Formula

C28H39N3O2

Molecular Weight

449.63

References & Citations

[1]Moye LS, et al. Delta opioid receptor agonists are effective for multiple types of headache disorders. Neuropharmacology. 2019 Apr;148:77-86.|[2]Bilsky EJ, et al. SNC 80, a selective, nonpeptidic and systemically active opioid delta agonist. J Pharmacol Exp Ther. 1995 Apr;273 (1) :359-66.|[3]Calderon SN, et al. Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+) -4-[ (alpha R) -alpha- ((2S,5R) -4-allyl-2,5-dimethyl-1-piperazinyl) -3- methoxybenzyl]-N, N-diethylbenzamide (SNC 80) : a highly selective, nonpeptide delta opioid receptor agonist. J Med Chem. 1994 Jul 8;37 (14) :2125-8.|[4]Vicente-Sanchez A, et al. The delta opioid receptor tool box. Neuroscience. 2016 Dec 3;338:145-159.|[5]Dripps IJ, et al. Role of signalling molecules in behaviours mediated by the δ opioid receptor agonist SNC80. Br J Pharmacol. 2018 Mar;175 (6) :891-901.|[6]Metcalf MD, et al. The δ opioid receptor agonist SNC80 selectively activates heteromeric μ-δ opioid receptors. ACS Chem Neurosci. 2012 Jul 18;3 (7) :505-9.