KSQ-4279
KSQ-4279 (USP1-IN-1) is a potent USP1 inhibitor and a selective PARP1 inhibitor. KSQ-4279 is promising for research of cancers[1].
Product Specifications
CAS Number
[2446480-97-1]
Product Name Alternative
USP1-IN-1
UNSPSC
12352005
Target
Deubiquitinase; PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ksq-4279.html
Purity
99.9600
Solubility
DMSO : 80 mg/mL (ultrasonic)
Smiles
FC(F)(C1=CN(C(C)C)C(C2=CC=C(CN3N=CC4=C3N=C(C5=C(C6CC6)N=CN=C5OC)N=C4)C=C2)=N1)F
Molecular Formula
C27H25F3N8O
Molecular Weight
534.54
References & Citations
[1]Natalie Y L Ngoi, et al. Targeting the DNA damage response beyond poly (ADP-ribose) polymerase inhibitors: novel agents and rational combinations. Curr Opin Oncol. 2022 Sep 1;34 (5) :559-569.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP1; USP1
Available Sizes
Curated Selection
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