Frunevetmab

Frunevetmab (NV-02) is a felinized anti-nerve growth factor (NGF) monoclonal antibody with a Kd of 20 pM. Frunevetmab can effectively decrease osteoarthritis (OA) pain in cats[1][2].

Product Specifications

CAS Number

[1708936-80-4]

Product Name Alternative

NV-02; PG110; ABT-110

UNSPSC

12352203

Target

Trk Receptor

Type

Inhibitory Antibodies

Related Pathways

Neuronal Signaling; Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/frunevetmab.html

Purity

95.00

Solubility

10 mM in DMSO

Smiles

[Frunevetmab]

Molecular Weight

(148 kDa)

References & Citations

[1]Margaret E Gruen, et al. Frunevetmab, a felinized anti-nerve growth factor monoclonal antibody, for the treatment of pain from osteoarthritis in cats. J Vet Intern Med. 2021 Nov;35 (6) :2752-2762. |[2]Margaret E Gruen, et al. Frunevetmab, a felinized anti-nerve growth factor monoclonal antibody, for the treatment of pain from osteoarthritis in cats. J Vet Intern Med. 2021 Nov;35 (6) :2752-2762. |[3]D P Gearing, et al. In Vitro and In Vivo Characterization of a Fully Felinized Therapeutic Anti-Nerve Growth Factor Monoclonal Antibody for the Treatment of Pain in Cats. J Vet Intern Med. 2016 Jul;30 (4) :1129-37.