FIDAS-3

FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A) . FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-3 has anticancer activities[1][2].

Product Specifications

CAS Number

[1266684-01-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Wnt

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/fidas-3.html

Purity

99.40

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CN(C)C1=CC=C(/C=C/C2=C(F)C=CC=C2F)C=C1

Molecular Formula

C16H15F2N

Molecular Weight

259.29

Precautions

H302, H315, H319

References & Citations

[1]Zhang W, et al. Fluorinated N, N-dialkylaminostilbenes repress colon cancer by targeting methionine S-adenosyltransferase 2A. ACS Chem Biol. 2013 Apr 19;8 (4) :796-803.|[2]Zhang W, et al. Fluorinated N, N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. J Med Chem. 2011 Mar 10;54 (5) :1288-97.