ONO-8430506

ONO-8430506 is an orally bioavailable and potent autotaxin (ATX) /ENPP2 inhibitor with the IC90 of 100 nM for ATX activity in mouse plasma[1][2][3].

Product Specifications

CAS Number

[1354805-08-5]

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ono-8430506.html

Purity

99.90

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C12CCC(CC1)(C2)CC(N3CC4=C(CC3)C5=C(N4CC6=CC=C(C=C6)F)N=CC=C5)=O)O

Molecular Formula

C27H28FN3O3

Molecular Weight

461.53

References & Citations

[1]Matthew G K Benesch, et al. Inhibition of autotaxin delays breast tumor growth and lung metastasis in mice. FASEB J. 2014 Jun;28 (6) :2655-66.|[2]Hiroshi Saga, et al. A novel highly potent autotaxin/ENPP2 inhibitor produces prolonged decreases in plasma lysophosphatidic acid formation in vivo and regulates urethral tension. PLoS One. 2014 Apr 18;9 (4) :e93230.|[3]Yuzo Iwaki, et al. ONO-8430506: A Novel Autotaxin Inhibitor That Enhances the Antitumor Effect of Paclitaxel in a Breast Cancer Model. ACS Med Chem Lett. 2020 May 14;11 (6) :1335-1341.